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This European Standard covers the energy performance calculation of mechanical ventilation and air conditioning systems, including humidification and dehumidification. It takes into account the generation (air handling unit) and distribution (duct system) parts. It includes a simplified calculation of adiabatic cooling systems. It does not cover the emission part (calculation of the required volume flow rates and/or supply air conditions), which is covered in EN 16798-7. It does not include the calculation of heating/cooling generation. This method is focussed on large customized ventilation and air conditioning systems, typically used in commercial buildings, although the application is not restricted on the basis of building or space use type. A calculation method for ventilation systems with integrated heating/cooling generation, including domestic hot water generation, using a monthly or seasonal calculation interval or a bin method, is provided in a separate standard, EN 16798-5-2. This method does not include humidification and dehumidification or adiabatic cooling. Table 1 shows the relative position of this standard within the set of EPB standards in the context of the modular structure as set out in EN ISO 52000 1. NOTE 1 In CEN ISO/TR 52000 2 the same table can be found, with, for each module, the numbers of the relevant EPB standards and accompanying technical reports that are published or in preparation. NOTE 2 The modules represent EPB standards, although one EPB standard might cover more than one module and one module might be covered by more than one EPB standard, for instance a simplified and a detailed method respectively. See also Clause 2 and Tables A.1 and B.1.