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Scope

1.1 This practice covers the introduction of foreign materials into the body that may have an impact on the immune system. One possible effect is that the immune system will be depressed or certain cell types may be affected. Immunotoxicity may be determined with blood and tissue samples from the animals used in the other biocompatibility test procedures such as implantation and blood contact test protocols. It is also possible to use these techniques with blood samples from human patients in a clinical trial. Any procedures with human subjects should follow the appropriate rules of the local institutional review board and the appropriate regulatory agencies. This document may serve as an annex to Practice F748.

1.2 The material may affect the humoral immune response, the cell mediated response, or both.

1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety and health practices and determine the applicability of regulatory limitations prior to use.

Keywords

B cells; biocompatibility; cell mediated immunity; complement; humoral immunity; immunotoxicity; T cells; ICS Number Code 11.100 (Laboratory medicine); 13.300 (Protection against dangerous goods); 19.020 (Test conditions and procedures in general)

To find similar documents by ASTM Volume:

13.01 (Medical and Surgical Materials and Devices)

To find similar documents by classification:

11.100 (Laboratory medicine)

13.300 (Protection against dangerous goods Including performance requirements for dangerous goods, their handling, storage, transportation, marking, labelling, etc. Nuclear fissile materials, see 27.120.30 Explosives, see 71.100.30)

19.020 (Test conditions and procedures in general)

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